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What is yellow fever? Yellow fever is a serious disease caused by the yellow fever virus. It is found in certain parts of Africa and South America. Yellow fever is spread through the bite of an infected mosquito. It cannot be spread person to person by direct contact. People with yellow fever disease usually have to be hospitalized. Yellow fever can cause: fever and flu-like symptoms jaundice (yellow skin or eyes) bleeding from multiple body sites liver, kidney, respiratory and other organ failure death (20 to 50% of serious cases) Yellow fever vaccine is a live, weakened virus. It is given as a single shot. For people who remain at risk, a booster dose is recommended every 10 years. Yellow fever vaccine may be given at the same time as most other vaccines.