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Drug Info for rydapt

Midostaurin is used with other chemotherapy drugs to treat certain types of acute myeloid leukemia (AML; a type of cancer of the white blood cells). Midostaurin is also used to certain types of mastocytosis (a blood disorder in which there are too many mast cells [a certain kind of white blood cell]). Midostaurin is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop the spread of mast and cancer cells.

Swallow the capsule whole. Do not crush, break, chew, or open it.

Missed dose: If you miss a dose or vomit after taking your medicine, skip the missed dose and take your next regular dose. Do not use extra medicine to make up for a missed dose.

Oral routeYou may also receive medicines to help prevent nausea and vomiting.

Your doctor will tell you how much medicine to use. Do not use more than directed.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Store the medicine in the original package to protect from moisture.

Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

Oral routeIt is best to take this medicine with food or milk.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to midostaurin, or if you are pregnant.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

Oral routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

Tell your doctor if you have kidney disease, liver disease, or lung or breathing problems.

Oral routeThis medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant within 7 days before starting treatment. Use an effective form of birth control to keep from getting pregnant during treatment and for 4 months after the last dose. Males who are taking this medicine, with female partners who can become pregnant must use effective birth control during treatment and for 4 months after the last dose.

Do not breastfeed during treatment and for 4 months after your last dose.

This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

Oral routeCancer medicine can cause nausea or vomiting, sometimes even after you receive medicine to prevent these effects. Ask your doctor or nurse about other ways to control any nausea or vomiting that might happen.

Oral routeThis medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.

This medicine may cause lung or breathing problems (including interstitial lung disease, pneumonitis).

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

Some medicines can affect how midostaurin works. Tell your doctor if you are using boceprevir, bupropion, carbamazepine, clarithromycin, cobicistat, conivaptan, danoprevir/ritonavir, diltiazem, elvitegravir/ritonavir, enzalutamide, idelalisib, indinavir/ritonavir, itraconazole, ketoconazole, lopinavir/ritonavir, mitotane, nefazodone, nelfinavir, paritaprevir/ritonavir and (ombitasvir and/or dasabuvir), phenytoin, posaconazole, rifampin, ritonavir, rosuvastatin, saquinavir/ritonavir, St John€™s wort, tipranavir/ritonavir, troleandomycin, voriconazole, or birth control pills (including ethinyl estradiol, levonorgestrel).

  • Dry mouth, fruit-like breath odor, nausea, vomiting, stomach pain, tiredness
  • Fainting, dizziness, lightheadedness
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Chest pain, trouble breathing
  • Bone, joint, or muscle pain
  • Fast, pounding, or uneven heartbeat
  • Fever, chills, cough, stuffy or runny nose, sore throat, body aches
  • Unusual bleeding, bruising, or weakness
  • Headache
  • Constipation, diarrhea
  • Sores or white patches on your lips, mouth, or throat
  • Small red or purple spots on skin