Pioglitazone Hcl-Glimepiride

( Generic Duetact )

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Pioglitazone Hcl-Glimepiride

Drug Info for pioglitazone hcl-glimepiride

Glimepiride is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Glimepiride lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. This medication will only help lower blood sugar in people whose bodies produce insulin naturally. Glimepiride is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may occur if high blood sugar is not treated). Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

Duetact is indicated for the treatment of diabetes type 2. It contains glimepiride and pioglitazone and work to lower the levels of glucose in the blood. It is commonly prescribed together with diet and exercise to help improve blood glucose levels in patients with this condition. Duetact is indicated for use in adults and is available as a tablet.

  • Pioglitazone HCl/Glimepiride
  • Duetact

Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

Oral routeIt is best to take this medicine with food or milk. Take this medicine with the first meal of the day.

This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

Missed dose: If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule, unless your doctor tells you otherwise. Do not double doses.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to glimepiride, pioglitazone, or a sulfa drug.

Tell your doctor if you are pregnant or breastfeeding. If you had problems ovulating or have irregular periods, this medicine may cause you to ovulate, which could lead to pregnancy if you are sexually active. Talk to your doctor about effective birth control while you are using this medicine.

Tell your doctor if you have kidney disease, liver disease, heart disease, heart failure, adrenal or pituitary gland problems, G6PD deficiency, macular edema (swelling of the back of the eye), or a history of alcohol abuse or bladder cancer. Also tell your doctor if you drink alcohol.

This medicine may cause the following problems:Increased risk of heart or blood vessel problemsLow blood sugar levelsLiver problemsIncreased risk for bladder cancer if you use this medicine for a long timeIncreased risk for broken bones

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

Shaking, trembling, sweating, fast or pounding heartbeat, lightheadedness, hunger, confusion

Some medicines can affect how this medicine works. Tell your doctor about all other medicines that you are using, including the following:Clonidine, fluconazole, gemfibrozil, miconazole, reserpine, rifampin, topiramateBeta-blocker medicineInsulin or other oral diabetes medicine.

If you also take colesevelam, take this medicine at least 4 hours before you take colesevelam.

Women: This medicine may cause you to ovulate if you have not gone through menopause yet. This could happen even if you have a history of irregular periods or problems ovulating. Talk to your doctor about effective birth control.

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Change in how much or how often you urinate, painful urination, lower back or side pain, blood in your urine
  • Shaking, trembling, sweating, fast or pounding heartbeat, lightheadedness, hunger, confusion
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Blurred vision or changes in vision
  • Rapid weight gain, swelling in your hands, ankles, or feet, trouble breathing
  • Cough, runny or stuffy nose, sore throat
  • Diarrhea, mild nausea, or vomiting
  • Headache