Ofev

Ofev is indicated for the treatment of idiopathic pulmonary fibrosis. This condition causes scarring of the lung tissue that results in difficulty breathing. Ofev slows down the progression of this disease but, it is not a cure. It is indicated for use by adults and is available as a capsule.

• Ofev

• Esbriet
• Ofev
• Pirfenidone

• Capsule

• By mouth

Your doctor will tell you how much medicine to use. Do not use more than directed.

Oral routeIt is best to take this medicine with food or milk.

Swallow the capsule whole with liquids. Do not crush, break, or chew it.

Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

Missed dose: Skip the missed dose and go back to your regular dosing schedule. Do not take extra medicine to make up for a missed dose.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to nintedanib, or if you are pregnant.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before starting treatment. Use an effective form of birth control during treatment and for at least 3 months after the last dose.

Do not breastfeed during treatment with this medicine.

Tell your doctor if you have liver disease, bleeding problems, or heart or blood vessel disease. Tell your doctor if you have stomach or digestion problems or have had recent surgery in your abdomen or stomach.

This medicine may cause the following problems:Liver problemsStomach or bowel problems (including diarrhea, nausea, vomiting)Increased risk of bleeding, heart attack, or strokeIncreased risk of a tear (perforation) in your stomach or bowelsIncreased protein in the urine (proteinuria)

Some women who use this medicine have become infertile (unable to have children). Talk with your doctor before using this medicine if you plan to have children.

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Some medicines can affect how nintedanib works. Tell your doctor if you are using the following:Carbamazepine, erythromycin, ketoconazole, phenytoin, rifampicin, St John's wortBlood thinner (including aspirin, warfarin)NSAIDs (including diclofenac, ibuprofen, naproxen)Steroid medicine

Do not smoke before and during treatment with this medicine.

This medicine may cause the following problems:Liver problemsIncreased risk of bleeding, heart attack, or strokeIncreased risk of a tear (perforation) in your digestive system

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

• Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
• Bloody or cloudy urine, difficult or painful urination, swelling of the face, feet, or lower legs, weight gain
• Chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, unusual sweating, faintness
• Severe diarrhea, nausea, vomiting, stomach pain
• Unusual bleeding, bruising, or weakness
• Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Dizziness
• Headache, back pain
• Tiredness
• Weight loss or loss of appetite