( Posaconazole )

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Drug Info for posaconazole

Posaconazole is used to prevent serious fungal infections that can spread throughout the body in adults and children 2 years of age and older with a weakened ability to fight infection. Posaconazole delayed-release tablets are used to treat invasive aspergillosis (a serious fungal infection that begins in the lungs and spreads through the bloodstream to other organs) in adults and teenagers 13 years of age and older. Posaconazole oral suspension is also used to treat yeast infections of the mouth and throat including yeast infections in adults and teenagers 13 years of age and older that could not be treated successfully with other medications. Posaconazole is in a class of medications called azole antifungals. It works by slowing the growth of fungi that cause infection.

  • Liquid
  • Delayed Release Tablet

Missed dose: Delayed-release tablet: Take your dose of medicine as soon as you remember. If it is less than 12 hours until your next dose, just skip the missed dose and go back to your regular schedule. Do not take extra medicine to make up for the missed dose. Oral liquid: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Do not freeze the oral liquid.

Your doctor will tell you how much medicine to use. Do not use more than directed.

Delayed-release tablet: Swallow the tablet whole. Do not crush, break, or chew it. You may take this medicine with or without food.

Oral liquid: Shake the oral liquid well before using. Use the dosing spoon in the package to measure the dose. Rinse the measuring spoon with water after use and before storage.Take this medicine with a full meal or within 20 minutes after a meal. If you cannot eat a full meal, take it with a liquid nutritional supplement or an acidic drink, including ginger ale.

Delayed-release oral liquid: Do not open the packet until you are ready to prepare the medicine.Remove the cap from the mixing liquid and push the bottle adapter into the neck of the bottle. Remove 9 milliliters (mL) of mixing liquid using the provided blue syringe and put back the cap on the bottle. Use only the provided mixing liquid and syringes.Mix the 9 mL liquid and the entire contents of 1 packet in the provided mixing cup. Shake the cup for 45 seconds and make sure the powder is mixed. The mixture should look cloudy and free from clumps.Take the liquid within 1 hour of mixing. Throw away any unused liquid.Oral routeIt is best to take this medicine with food or milk.

Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup. You may hand wash and reuse the provided mixing cup and syringes.

Posaconazole oral liquid works differently than the delayed-release tablet or delayed-release oral liquid, even at the same dose. Do not switch from one form to another unless your doctor tells you to.

Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.

This medicine is not right for everyone. Do not use if you had an allergic reaction to posaconazole or similar medicines, or if you have inherited fructose intolerance.

Unusual bleeding, bruising, or weakness

Keep all medicine out of the reach of children. Never share your medicine with anyone.

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

This medicine can cause the following problems:Heart rhythm problems, including QT prolongation, torsades de pointesLiver problems

Tell your doctor if you are pregnant or breastfeeding, or if you have a history of heart disease, kidney disease, liver disease, or heart rhythm problems (including QT prolongation).

Do not use this medicine together with atorvastatin, lovastatin, pimozide, quinidine, simvastatin, sirolimus, venetoclax, or an ergot medicine (including ergotamine, dihydroergotamine).

Do not drink alcohol while you are using this medicine.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

Some foods and medicines can affect how posaconazole works. Tell your doctor if you are using any of the following:Cimetidine, cyclosporine, digoxin, efavirenz, esomeprazole, glipizide, metoclopramide, phenytoin, rifabutin, tacrolimusBenzodiazepine medicine (including alprazolam, triazolam)Blood pressure medicine (including verapamil, diltiazem, felodipine, nifedipine, nicardipine)Medicine to treat HIV/AIDS (including atazanavir, efavirenz, fosamprenavir, ritonavir)Vinca alkaloids (including vinblastine, vincristine)

  • Fever, chills, cough, sore throat, body aches
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Fast, slow, pounding, or uneven heartbeat
  • Dry mouth, increased thirst, muscle cramps
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Unusual bleeding, bruising, or weakness
  • Severe diarrhea
  • Sores or white patches on your lips, mouth, or throat
  • Headache
  • Mild diarrhea, constipation