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Drug Info for kevzara

Sarilumab injection is used alone or with other medications to treat rheumatoid arthritis (RA: condition in which the body attacks its own joints causing pain, swelling, and loss of function). Sarilumab is usually used by people who were not helped by certain other drugs for RA or who could not take these medications. Sarilumab injection is in a class of medications called interleukin-6 (IL-6) receptor inhibitors. It works by blocking the activity of interleukin-6, a substance in the body that causes inflammation.

  • By injection

Injection routeYour doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin.

Do not remove the needle cap from the prefilled syringe or pen until you are ready to use it.

Allow the medicine to warm to room temperature for 30 minutes (for the prefilled syringe) or 60 minutes (for the prefilled pen) before using it. Do not warm this medicine in any other way.

Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

Injection routeA nurse or other health provider will give you this medicine.

Check the liquid in the prefilled syringe or pen. It should be clear and colorless or slightly yellow. Do not use this medicine if it is cloudy, discolored, if there are particles in it, or if the prefilled syringe is damaged or broken. Do not shake the medicine.

Injection routeYou may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.

Injection routeYou will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. Do not inject into skin areas that are red, bruised, tender, hard, or have scars or stretch marks.

This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

Injection routeThrow away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

Injection routeUse a new needle and syringe each time you inject your medicine. You might not use all of the medicine in each prefilled syringe or pen. Use each prefilled syringe and pen only one time. Do not save an open syringe or pen.

Injection routeIf you store this medicine at home, keep it in the refrigerator. Do not freeze. Keep the medicine in its original package until you are ready to use it. You may also keep the medicine at room temperature, away from heat, after removing it from the refrigerator. Throw away unused medicine after 14 days.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to sarilumab.

This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, diabetes, high cholesterol, stomach or bowel disease (including diverticulitis, ulcers), or a weak immune system (including HIV, cancer). Tell your doctor if you have any type of infection (including hepatitis B or tuberculosis) or an infection that keeps coming back.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

You will need a skin test for tuberculosis (TB) before you start using this medicine. Tell your doctor if you or anyone in your home has ever had a positive TB skin test or been exposed to TB.

This medicine may cause the following problems:Increased risk for serious infectionsStomach or bowel problems (perforations or tears)Increased risk of cancerHigh cholesterol in the blood

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

This medicine may interfere with vaccines. Ask your doctor before you get a flu shot or any other vaccines.

Some medicines can affect how sarilumab works. Tell your doctor if you are using atorvastatin, lovastatin, theophylline, warfarin, or birth control pills.

  • Bloody, black, or tarry stools, severe stomach pain, diarrhea
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Vomiting of material that looks like coffee grounds
  • Fever, chills, cough, stuffy or runny nose, sore throat, body aches
  • Unusual bleeding, bruising, or weakness
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, yellow skin or eyes
  • Swollen glands in the neck, underarms, or groin
  • Pain, itching, burning, swelling, bleeding, or a lump under your skin where the shot was given