Depakote Sprinkles

( Divalproex Sodium )

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Divalproex Sodium

Drug Info for divalproex sodium

Valproic acid is used alone or with other medications to treat certain types of seizures. Valproic acid is also used to treat mania (episodes of frenzied, abnormally excited mood) in people with bipolar disorder (manic-depressive disorder; a disease that causes episodes of depression, episodes of mania, and other abnormal moods). It is also used to prevent migraine headaches but not to relieve headaches that have already begun. Valproic acid is in a class of medications called anticonvulsants. It works by increasing the amount of a certain natural substance in the brain.

Divalproex is a medication used to treat seizures (epilepsy), bipolar disorder, and to prevent migraine headaches. Divalproex most likely works by affecting levels of certain chemicals in the brain. Divalproex is a generic medication also referred to as valproate, valproic acid, and sodium valproate. Divalproex began to be used as a medication in the 1960s. In the treatment of seizures and bipolar disorder, divalproex use is fairly common.

  • Divalproex Sodium
  • Depakote
  • Depakote ER
  • Depakote Sprinkles
  • Delayed Release Capsule
  • Delayed Release Tablet
  • Coated Tablet
  • Long Acting Tablet

Sprinkle capsule: You may open the capsule and pour the medicine onto a teaspoonful of soft food (including pudding or applesauce). Stir this mixture well and swallow it without chewing.

Part of the medicine may pass into your stool after your body has absorbed the medicine. Check with your doctor right away if this happens.

This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose. If you miss 2 or more doses, call your doctor.

Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

You may take this medicine with food to decrease stomach upset.

Capsule, tablet, delayed-release tablet, or extended-release tablet: Swallow the medicine whole. Do not crush, break, or chew it.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to divalproex, valproate sodium, or valproic acid. Do not use it to prevent migraine headaches if you are pregnant, or if you have liver disease, or certain genetic disorders (including urea cycle disorder or mitochondrial disorder).

It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.

Tell your doctor if you are breastfeeding, or if you have kidney disease, blood disease, pancreas problems, a viral infection (including HIV or cytomegalovirus infection), or a history of depression or mental health problems.

This medicine may cause the following problems:Liver problemsPancreatitis (swelling of the pancreas)Hyperammonemic encephalopathy (too much ammonia in your blood)Depression or thoughts of suicideBleeding problems (including thrombocytopenia)Hypothermia (low body temperature)Drug reaction with eosinophilia and systemic symptoms (DRESS), which may damage the organs, including the liver, kidney, or heart

This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

Talk with your doctor before using this medicine if you plan to have children. Some men who use this medicine have become infertile (unable to have children).

Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

Some medicines can affect how divalproex sodium works. Tell your doctor if you are using any of the following: Amitriptyline, aspirin, cannabidiol, chlorpromazine, clonazepam, diazepam, lorazepam, methotrexate, nortriptyline, propofol, rifampin, ritonavir, rufinamide, tolbutamide, zidovudineBirth control pillBlood thinner (including warfarin)Carbapenem antibiotic (including ertapenem, imipenem, meropenem)Other seizure medicines (including carbamazepine, ethosuximide, felbamate, lamotrigine, phenobarbital, phenytoin, primidone, topiramate)

Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used together with this medicine.

This medicine may cause depression or thoughts of suicide. Tell your doctor if you have a history of depression or mental illness.

This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.

Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

This medicine may cause the following problems:Liver problemsPancreatitisHyperammonemic encephalopathy (too much ammonia in your blood)Thrombocytopenia (decrease in blood cells that affect clotting)Hypothermia (low body temperature)Drug reaction with eosinophilia and systemic symptoms (DRESS), which may damage organs such as the liver, kidney, or heart

  • Sudden and severe stomach pain, nausea, vomiting, lightheadedness
  • Fever, rash, swollen glands in the neck, armpit, or groin
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Confusion, problems with memory, unusual drowsiness, clumsiness
  • Dark urine or pale stools, loss of appetite, stomach pain, yellow skin or eyes
  • Unusual bleeding, bruising, or weakness
  • Thoughts of hurting yourself, depression, unusual changes in behavior or moods
  • Tiny red dots on the skin, especially on the lower legs
  • Trouble sleeping, tremor
  • Diarrhea, stomach upset
  • Hair loss
  • Vision changes, dizziness, headache
  • Tiredness, sleepiness