Deferasirox

( Generic Jadenu Exjade Jadenu Sprinkle )

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Deferasirox

Drug Info for deferasirox

Deferasirox is used to treat adults and children 2 years of age and older who have too much iron in their body because they received many blood transfusions. It is also used to treat adults and children 10 years of age and older who have too much iron in their body because of a genetic blood disorder called non–transfusion-dependent thalassemia (NTDT). Deferasirox is in a class of medications called iron chelators. It works by attaching to iron in the body so that it can be excreted (removed from the body) in feces.

  • Exjade
  • Jadenu
  • Jadenu Sprinkle
  • Granule
  • Tablet
  • Tablet for Suspension

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep the bottle closed tightly and away from moisture.

Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

Granule: Sprinkle the granules on soft food (including applesauce or yogurt) immediately before taking it orally.Take the granules at the same time each day on an empty stomach or with a light meal.

Tablet: Swallow the tablet whole with water or other liquids.Take the tablet at the same time each day on an empty stomach or with a light meal.If you have trouble swallowing the whole tablet, it may be crushed and mixed with soft foods (including apple sauce or yogurt) immediately before taking it orally.

Tablet for suspension: Dissolve the tablet in water, orange juice, or apple juice. Mix well and drink the mixture right away. To make sure you get all of the medicine, add more liquid to the glass, and then drink all of it. Do not chew or swallow the tablet.Take the medicine at the same time each day on an empty stomach, at least 30 minutes before you eat.

Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to deferasirox.

Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, blood or bone marrow problems, cancer, diabetes, eye problems (including cataracts, glaucoma), hearing problems, or stomach or bowel problems (including ulcers or bleeding).

This medicine can cause the following problems: Kidney problems, including kidney failureLiver problemsStomach or bowel bleeding, ulcer, or perforation (may be life-threatening)Anemia or other problems with blood cell countsSerious skin reactions, including drug reaction with eosinophilia and systemic symptoms (DRESS)Changes in vision or hearing

This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

This medicine may make you dizzy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

Rapid weight gain, swelling in your face, hands, ankles, or feet

Unusual bleeding, bruising, or weakness

Do not take antacids that contain aluminum while you are using this medicine.

There are many medicines that can interact with deferasirox. Make sure your doctor knows the names of all the medicines you use, especially the following:Alfentanil, alosetron, aprepitant, buspirone, busulfan, cholestyramine, colesevelam, colestipol, conivaptan, cyclosporine, darifenacin, darunavir, dasatinib, dihydroergotamine, dronedarone, duloxetine, eletriptan, eplerenone, ergotamine, everolimus, felodipine, fentanyl, indinavir, lopinavir, lovastatin, lurasidone, maraviroc, melatonin, midazolam, nisoldipine, paclitaxel, phenobarbital, phenytoin, pimozide, quetiapine, quinidine, ramelteon, repaglinide, rifampicin, ritonavir, saquinavir, sildenafil, simvastatin, sirolimus, tacrine, tacrolimus, theophylline, ticagrelor, tipranavir, tizanidine, tolvaptan, triazolam, vardenafilBirth control pills or patchesBisphosphonate medicineBlood thinner (including warfarin)Coffee or products that contain caffeineNSAID pain medicine (including aspirin, celecoxib, diclofenac, ibuprofen, naproxen)Steroid medicine (including budesonide, fluticasone, prednisolone, prednisone)

This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

This medicine may make you dizzy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Rapid weight gain, swelling in your face, hands, ankles, or feet
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Bloody or black, tarry stools, severe stomach pain, vomiting of blood or material that looks like coffee grounds
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, yellow skin or eyes
  • Decrease in how much or how often you urinate, bloody or cloudy urine
  • Unusual bleeding, bruising, weakness
  • Fever, chills, cough, sore throat, body aches
  • Hearing problems or loss of hearing
  • Vision changes, eye pain
  • Mild nausea, vomiting, diarrhea, stomach pain
  • Mild rash