Cymbalta

( Duloxetine Hcl )

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Duloxetine Hcl

Drug Info for duloxetine hcl

Duloxetine is used to treat depression in adults and generalized anxiety disorder (GAD; excessive worry and tension that disrupts daily life and lasts for 6 months or longer) in adults and children 7 years of age and older. Duloxetine is also used to treat pain and tingling caused by diabetic neuropathy (damage to nerves that can develop in people who have diabetes) in adults and fibromyalgia (a long-lasting condition that may cause pain, muscle stiffness and tenderness, tiredness, and difficulty falling asleep or staying asleep) in adults and children 13 years of age and older. It is also used to treat ongoing bone or muscle pain such as lower back pain or osteoarthritis (joint pain or stiffness that may worsen over time) in adults. Duloxetine is in a class of medications called selective serotonin and norepinephrine reuptake inhibitors (SNRIs). It works by increasing the amounts of serotonin and norepinephrine, natural substances in the brain that help maintain mental balance and stop the movement of pain signals in the brain.

Cymbalta is a medication used to treat some mental health disorders, fibromyalgia, and pain disorders. Cymbalta belongs to a class of medications called serotonin norepinephrine reuptake inhibitors (SNRIs). Cymbalta is the brand name of the drug duloxetine. The patent of Cymbalta was granted in 1990, and the drug has since been approved for use in the US. In the treatment of some mental health and pain disorders, Cymbalta use is fairly common.

  • Cymbalta
  • Drizalma Sprinkle
  • Irenka
  • Capsule
  • Delayed Release Capsule

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

Delayed-release capsule: Swallow the capsule whole. Do not crush, chew, break, or open it. Do not open the Cymbalta® delayed-release capsule and sprinkle the contents on food or in liquids.

If you have trouble swallowing the Drizalma Sprinkle„¢ delayed release capsule: You may open the capsule and sprinkle the contents over one tablespoon (15 mL) of applesauce. Swallow the mixture right away and do not save any of the mixture to use later.You may open the capsule and pour the contents to an all plastic catheter tip syringe and add 50 mL of water. Do not use other liquids. Gently shake it for 10 seconds, and then use it through a nasogastric tube. Rinse with additional water (about 15 mL) if needed.

This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to duloxetine.

Unusual moods or behaviors, worsening depression, thoughts about hurting yourself, trouble sleeping

Unusual bleeding or bruising

Lightheadedness, dizziness, or fainting

Restlessness, fever, fast heartbeat, sweating, muscle spasms, diarrhea, seeing or hearing things that are not there

This medicine can increase thoughts of suicide. Tell your doctor right away if you start to feel depressed and have thoughts about hurting yourself.

This medicine may cause blurred vision, dizziness, drowsiness, trouble with thinking, or trouble with controlling body movements, which may lead to falls, fractures, or other injuries. Do not drive or do anything that could be dangerous until you know how this medicine affects you. Stand up slowly to avoid falls.

Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

This medicine may cause the following problems: Serious liver problemsSerotonin syndrome, when used with certain medicinesIncreased risk of bleeding problemsSerious skin reactions, including erythema multiforme, Stevens-Johnson syndromeLow sodium levels in the bloodSexual problems

Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, bleeding problems, diabetes, digestion problems, glaucoma, heart disease, high or low blood pressure, or problems with urination. Tell your doctor if you smoke or you have a history of seizures, mental health problems (including bipolar disorder, mania), or drug or alcohol addiction.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

Do not drink alcohol while you are using this medicine.

Some medicines can affect how duloxetine works. Tell your doctor if you are using any of the following:Buspirone, cimetidine, ciprofloxacin, enoxacin, fentanyl, fluvoxamine, lithium, meperidine, methadone, St John's wort, theophylline, tramadol, tryptophan, warfarinAmphetaminesBlood pressure medicineDiuretic (water pill)Medicine for heart rhythm problems (including flecainide, propafenone, quinidine)Medicine to treat migraine headaches (including triptans)NSAID pain or arthritis medicine (including aspirin, celecoxib, diclofenac, ibuprofen, naproxen)Other medicine to treat depression or mood disorders (including amitriptyline, desipramine, fluoxetine, imipramine, nortriptyline, paroxetine)Phenothiazine medicine (including thioridazine)Stomach medicine (including famotidine, antacids containing aluminum or magnesium, PPIs)

Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

Do not take duloxetine if you have used an MAO inhibitor (MAOI) within the past 14 days. Do not start taking an MAO inhibitor within 5 days of stopping duloxetine. Ask your doctor if you are not sure if you take an MAOI, including linezolid or methylene blue injection.

  • Feeling more energetic than usual
  • Decrease in how much or how often you urinate
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Unusual moods or behaviors, worsening depression, thoughts about hurting yourself, trouble sleeping
  • Eye pain, vision changes, seeing halos around lights
  • Confusion, weakness, muscle twitching
  • Decrease in sexual ability, desire, drive, or performance
  • Unusual bleeding or bruising
  • Anxiety, restlessness, fever, fast heartbeat, sweating, muscle spasms, diarrhea, seeing or hearing things that are not there
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Lightheadedness, dizziness, fainting
  • Unusual drowsiness, sleepiness, or tiredness
  • Headache
  • Dry mouth, constipation, mild nausea
  • Decrease in appetite or weight