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Drug Info for captopril-hydrochlorothiazide

The combination of captopril and hydrochlorothiazide is used to treat high blood pressure. Captopril is in a class of medications called angiotensin-converting enzyme (ACE) inhibitors. It works by decreasing certain chemicals that tighten the blood vessels, so blood flows more smoothly. Hydrochlorothiazide is in a class of medications called diuretics ('water pills'). It works by causing the kidneys to get rid of unneeded water and salt from the body into the urine. High blood pressure is a common condition, and when not treated it can cause damage to the brain, heart, blood vessels, kidneys, and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

  • Capozide 50/25
  • Capozide 25/15

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

Swallow the tablet whole. Do not break, crush, or chew it.

It is best to take this medicine on an empty stomach, 1 hour before you eat a meal.

This medicine is not right for everyone. Do not use if you have had an allergic reaction to captopril, hydrochlorothiazide, another ACE inhibitor, or a sulfa drug, or if you are pregnant or cannot pass urine, or if you have a history of angioedema caused by an ACE inhibitor.

This medicine is not safe to take during pregnancy, especially in your second or third trimester. It could harm an unborn baby. Tell your doctor right away if you become pregnant.

Tell your doctor if you are breastfeeding, or if you have kidney disease (including patients on dialysis), liver disease, heart or blood vessel disease, heart failure, diabetes, gout, collagen-vascular disease (including lupus or scleroderma), or a history of asthma or allergies, or if you have had surgery of the nerves.

This medicine may cause the following problems:Angioedema (severe swelling), including head, neck, and intestinal swellingLow blood pressureLiver problemsKidney problemsHigh blood sugar and uric acidIncreased risk of skin cancer

This medicine could lower your blood pressure too much, especially when you first use it or if you are dehydrated. Stand or sit up slowly if you feel lightheaded or dizzy.

Drink plenty of fluids if you exercise, sweat more than usual, or have diarrhea or vomiting while you are using this medicine.

Do not stop using this medicine without asking your doctor, even if you feel well. This medicine will not cure your high blood pressure, but it will help keep it in the normal range. You may have to take blood pressure medicine for the rest of your life.

Tell any doctor or dentist who treats you that you are using this medicine, especially before you have any type of surgery or medical tests.

This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

Some medicines can affect how captopril/hydrochlorothiazide works. Tell your doctor if you are using any of the following:Amphotericin B, cholestyramine, colestipol, diazoxide, gold, lithium, methenamine, norepinephrine, probenecid, sulfinpyrazoneDiuretic (water pill)Insulin and oral diabetes medicineMuscle relaxantsNSAIDs (including aspirin, celecoxib, diclofenac, ibuprofen, naproxen)Other blood pressure medicineSteroid medicine (including cortisone, prednisone)

Ask your doctor before you use any medicine, supplement, or salt substitute that contains potassium.

Alcohol, narcotic pain medicine, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine.

Avoid using narcotic pain relievers, phenobarbital, or other sedatives.

Do not drink alcohol while you are using this medicine.

  • Dry mouth, increased thirst, muscle cramps, nausea, vomiting
  • Sores, reddish patch or irritated area, shiny bump, pink growth, or white, yellow or waxy scar-like area on the skin
  • Fever, chills, cough, sore throat, and body aches
  • Unusual bleeding, bruising, or weakness
  • Dark urine or pale stools, loss of appetite, stomach pain, yellow skin or eyes
  • Lightheadedness or fainting
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Change in how much or how often you urinate
  • Chest pain, fast, pounding, or uneven heartbeat
  • Confusion, weakness, numbness or tingling in your hands, feet, or lips
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Cough
  • Mild skin rash.
  • Hot, dry skin
  • Increased sweating