Actoplus Met

• Pioglitazone HCl-metFORMIN HCl
• Actoplus Met
• Actoplus Met XR

• Actoplus Met
• Actoplus met XR
• Alogliptin-metFORMIN HCl
• Alogliptin-Pioglitazone
• Appformin
• Appformin-D
• Avandamet
• Avandaryl
• D-Care DM2
• Dapagliflozin Pro-metFORMIN ER
• Duetact
• glipiZIDE-metFORMIN HCl
• Glucovance
• glyBURIDE-metFORMIN
• Glyxambi
• Invokamet
• Invokamet XR
• Janumet
• Janumet XR
• Jentadueto
• Jentadueto XR
• Juvisync
• Kazano
• Kombiglyze XR
• Oseni
• Pioglitazone HCl-Glimepiride
• Pioglitazone HCl-metFORMIN HCl
• PrandiMet
• Qtern
• Repaglinide-metFORMIN HCl
• sAXagliptin-metFORMIN ER
• Segluromet
• Soliqua
• Steglujan
• Synjardy
• Synjardy XR
• Trijardy XR
• Xigduo XR
• Xultophy

• Long Acting Tablet
• Tablet

• By mouth

Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

Oral routeIt is best to take this medicine with food or milk.

Swallow the extended-release tablet whole. Do not crush, break, or chew it.

If you take the extended-release tablet, part of the tablet may pass into your stools. This is normal and is nothing to worry about.

This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to pioglitazone or metformin.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

It is important to tell your doctor or dentist that you are using this medicine. You may need to stop using this medicine several days before having surgery or other procedures.

Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may interact with the dye used for an x-ray or a CT scan.

This medicine may cause the following problems:Congestive heart failureLactic acidosis (too much acid in the blood)Low blood sugarLiver problemsIncreased risk for bladder cancer if you use this medicine for a long timeIncreased risk for broken bones

Tell your doctor if you have kidney disease, liver disease, heart failure, edema (fluid retention or swelling), macular edema (swelling of the back of the eye), adrenal or pituitary gland disease, vitamin B12 deficiency, or a history of alcohol abuse or bladder cancer.

Tell your doctor if you are pregnant or breastfeeding. If you had problems ovulating or have irregular periods, this medicine may cause you to ovulate, which could lead to pregnancy if you are sexually active. Talk to your doctor about effective birth control while you are using this medicine.

Some things that can lead to low blood sugar are exercising more than normal or waiting too long to eat. Tell your doctor about any sudden change in your medical condition.

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. You will also need to check your blood sugar on a regular basis at home.

This medicine may increase the risk for bone fractures in women. Ask your doctor about ways to keep your bones strong to help prevent fractures.

Check with your doctor if blurred vision, decreased vision, or any other change in vision occurs during your treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

Shortness of breath with cold sweat and bluish-colored skin.

Severe vomiting with fever or diarrhea.

Unusual weakness, bruising, or pale skin.

Swelling in your hands, ankles, or feet.

Yellowing of your skin or the whites of your eyes.

Check with your doctor if blurred vision, decreased vision, or any other change in vision occurs during your treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

Do not drink alcohol while you are using this medicine.

Limit how much alcohol you drink.

Some things that can lead to low blood sugar are exercising more than normal or waiting too long to eat. Tell your doctor about any sudden change in your medical condition.

This medicine may increase the risk for bone fractures in women. Ask your doctor about ways to keep your bones strong to help prevent fractures.

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. You will also need to check your blood sugar on a regular basis at home.

Some medicines can affect how this medicine works. Tell your doctor about all other medicines that you are using, including the following:Acetazolamide, cimetidine, dichlorphenamide, dolutegravir, gemfibrozil, isoniazid, nicotinic acid, phenytoin, ranolazine, rifampin, topiramate, vandetanib, zonisamideBirth control pills (including estrogen)Blood pressure medicineDiuretic (water pill)Insulin or other oral diabetes medicineMedicine to treat mental illnessSteroid medicineThyroid medicine

Check with your doctor right away if you start having chest pain; shortness of breath; excessive swelling of the hands, wrist, ankles, or feet; or if you are rapidly gaining weight. These may be symptoms of a serious heart problem.

This medicine may cause a rare, but serious condition called lactic acidosis in some people. Call your doctor right away if you get sick, or if you have unusual tiredness, weakness, muscle pain, stomach pain, trouble breathing, fever, or nausea.

Tell your doctor right away if you have any of these symptoms: loss of appetite, nausea, vomiting, stomach pain, unusual tiredness or weakness, weight loss, or yellow eyes or skin. These may be symptoms of a serious liver problem.

This medicine may increase your risk for bladder cancer if you take it for more than 12 months. Tell your doctor right away if you have blood in the urine; a frequent, strong, or increased urge to urinate; painful urination; or pain in the back, lower abdomen, or stomach.

• Rapid breathing, trouble breathing, or stomach pain with nausea and vomiting.
• Severe joint pain
• Shortness of breath with cold sweat and bluish-colored skin.
• Yellowing of your skin or the whites of your eyes.
• Pain or swelling in your arms or legs without any injury.
• Severe vomiting with fever or diarrhea.
• Unusual weakness, bruising, or pale skin.
• Shaking, trembling, sweating, fast or pounding heartbeat, faintness, hunger, confusion
• Rapid weight gain, swelling in your hands, ankles, or feet
• Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
• Fast or troubled breathing, lightheadedness, severe weakness, tiredness, or confusion
• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Change in how much or how often you urinate, painful urination, lower back or side pain, blood in your urine
• Blurred vision or other changes in vision
• Rapid weight gain.
• Swelling in your hands, ankles, or feet.
• Diarrhea
• Muscle or joint pain.
• Cough, stuffy or runny nose, sore throat
• Mild nausea, diarrhea, or stomach upset.
• Headache
• Problems with your teeth.