Treximet

( Sumatriptan-Naproxen Sodium )

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Sumatriptan-Naproxen Sodium

Drug Info for sumatriptan-naproxen sodium

Prescription naproxen is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints), rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), juvenile arthritis (a form of joint disease in children), and ankylosing spondylitis (arthritis that mainly affects the spine). Prescription naproxen tablets, extended-release tablets, and suspension are also used to relieve shoulder pain caused by bursitis (inflammation of a fluid-filled sac in the shoulder joint), tendinitis (inflammation of the tissue that connects muscle to bone), gouty arthritis (attacks of joint pain caused by a build-up of certain substances in the joints), and pain from other causes, including menstrual pain (pain that happens before or during a menstrual period). Nonprescription naproxen is used to reduce fever and to relieve mild pain from headaches, muscle aches, arthritis, menstrual periods, the common cold, toothaches, and backaches. Naproxen is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation.

Your doctor will tell you how much medicine to use. Do not use more than directed. Use only when you have a migraine. Do not use this medicine for regular headaches.

Swallow the tablet whole. Do not break, crush, or chew it.

Children 12 years of age or older: If your headache does not improve after the first dose, do not take a second dose. Call your doctor.

Adults: If your headache does not improve after the first dose, wait at least 2 hours before you take a second dose. Do not take more than 2 tablets in 24 hours.

This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to sumatriptan, naproxen, aspirin, or similar medicines, or if you have a history of heart disease, heart attack, angina, stroke, transient ischemic attack (TIA), ischemic bowel disease, peripheral vascular disease, or severe liver disease. Do not use it right before or after a heart surgery called coronary artery bypass surgery.

Sudden or severe headache, problems with vision, speech, or walking

Unexplained weight gain, swelling in your hands, ankles, or feet

Unusual bleeding, bruising, or weakness

Tell your doctor if you are pregnant or breastfeeding. Do not use this medicine during the later part of pregnancy, unless your doctor says it is okay.

Tell your doctor if you have kidney disease, liver disease, anemia, asthma, bleeding problems, diabetes, fluid retention, high cholesterol, heart rhythm problems, high blood pressure, or a family history of heart disease. Tell your doctor if you have a history of seizures, ulcers, or stomach or bowel bleeding. Tell your doctor if you are on a low-salt diet or if you smoke or drink alcohol.

This medicine may cause the following problems:Increased risk of blood clots, heart attack, heart rhythm problems, or strokeStomach or bowel problems (including bleeding, ulcers, or perforation)Serotonin syndrome, when used with certain other medicinesKidney problemsLiver problemsSerious skin reactions, including exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms (DRESS)

This medicine may cause a delay in ovulation for women and may affect their ability to have children. If you plan to have children, talk with your doctor before using this medicine.

Your headaches may become worse if you use a headache medicine for 10 or more days per month. Write down how often your headaches occur and how often you use this medicine.

This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

Severe stomach pain, bloody or black stools

Do not use this medicine if you have taken an MAO inhibitor in the past 14 days or another migraine medicine within the past 24 hours.

Do not use aspirin or any other NSAID medicine (including celecoxib, diclofenac, diflunisal, ibuprofen, salsalate) unless your doctor says it is okay.

Some medicines can affect how sumatriptan/naproxen works. Tell your doctor if you are using any of the following:Cyclosporine, digoxin, lithium, methotrexate, pemetrexed, probenecidBlood pressure medicineBlood thinner (including warfarin)Diuretic (water pill)Medicine to treat depressionSteroid medicine

Your headaches may become worse if you use a headache medicine for 10 or more days per month. Write down how often your headaches occur and how often you use this medicine.

This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Coughing up blood, numbness or weakness in your arm or leg, or on one side of your body, pain in your lower leg
  • Seizure
  • Unusual bleeding, bruising, or weakness
  • Bloody or black, tarry stools, severe stomach pain, vomiting blood or material that looks like coffee grounds
  • Fast or slow, pounding, or uneven heartbeat
  • Unexplained weight gain, swelling in your hands, ankles, or feet
  • Chest pain that may spread, trouble breathing, unusual sweating, fainting
  • Blistering, peeling, or red skin rash
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest discomfort, jaw or neck tightness
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Anxiety, restlessness, fever, muscle spasms, diarrhea, seeing or hearing things that are not there
  • Change in how much or how often you urinate, painful or difficult urination
  • Sudden or severe headache, problems with vision, speech, or walking
  • Vision changes that are not part of a usual migraine