Tnkase

• TNKase

• Activase
• Cathflo Activase
• Kinlytic
• Retavase
• Retavase Half-Kit
• TNKase

• Injectable
• Kit

• Into a vein

Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. The medicine must be given slowly, so the needle will have to remain in place for at least 5 seconds.

Injection routeA nurse or other health provider will give you this medicine.

This medicine is not right for everyone. You should not receive this medicine if you had an allergic reaction to tenecteplase, or if you have active bleeding, uncontrolled high blood pressure, surgery or trauma within 2 months, brain cancer, blood vessel disease, or known bleeding.

Tell your doctor if you are pregnant or breastfeeding, or if you have bleeding problems, blood clotting problems, heart failure, or heart rhythm problems.

This medicine may cause the following problems:Bleeding problemsBlood clotting problems, including thromboembolism

Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Coughing up blood.

Fever.

Heavy vaginal bleeding.

Lightheadedness or fainting.

New or unexplained bruising, bleeding, swelling, or pain anywhere in your body.

Numbness (loss of feeling), tingling, pain, or darkening of the skin of your toes.

Numbness or weakness in your arm or leg, or on one side of your body.

Sudden or severe headache, problems with vision, speech, or walking.

This medicine dissolves blood clots in the body, which increases your risk of bleeding problems. Be extra careful to avoid injuries until the effects of the medicine have worn off. Do not get out of bed without help.

Make sure your doctor knows if you are using dipyridamole (Persantine®), a blood thinner such as warfarin (Coumadin®) or heparin, or pain or arthritis medicines such as aspirin, ibuprofen, naproxen, Motrin®, Advil®, or Aleve®. There are other medicines that may interact with tenecteplase. Make sure your doctor knows about all other medicines you have used recently.

Watch for any bleeding from any skin punctures, such as around your IV or where blood was drawn from your arm. Also, check for blood in your urine or bowel movements. If you have any bleeding or injuries, tell your doctor or nurse right away.

• Lightheadedness or fainting
• Sudden or severe headache, problems with vision, speech, or walking
• Blood in the urine or stools
• Fever
• Numbness or weakness in your arm or leg, or on one side of your body.
• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Numbness, tingling, pain, or darkening of the skin of your toes
• Numbness (loss of feeling), tingling, pain, or darkening of the skin of your toes.
• Numbness or weakness in your arm or leg, or on one side of your body
• Chest pain, trouble breathing, coughing or vomiting blood
• Unusual bruising, bleeding, swelling, or pain anywhere in your body
• Sudden or severe headache, problems with vision, speech, or walking.
• Nausea or vomiting