Synjardy Xr

• Synjardy
• Synjardy XR

• Actoplus Met
• Actoplus met XR
• Alogliptin-metFORMIN HCl
• Alogliptin-Pioglitazone
• Appformin
• Appformin-D
• Avandamet
• Avandaryl
• D-Care DM2
• Dapagliflozin Pro-metFORMIN ER
• Duetact
• glipiZIDE-metFORMIN HCl
• Glucovance
• glyBURIDE-metFORMIN
• Glyxambi
• Invokamet
• Invokamet XR
• Janumet
• Janumet XR
• Jentadueto
• Jentadueto XR
• Juvisync
• Kazano
• Kombiglyze XR
• Oseni
• Pioglitazone HCl-Glimepiride
• Pioglitazone HCl-metFORMIN HCl
• PrandiMet
• Qtern
• Repaglinide-metFORMIN HCl
• sAXagliptin-metFORMIN ER
• Segluromet
• Soliqua
• Steglujan
• Synjardy
• Synjardy XR
• Trijardy XR
• Xigduo XR
• Xultophy

• Tablet
• Long Acting Tablet

• By mouth

Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

Swallow the extended-release tablet whole. Do not crush, break, or chew it. A part of the extended-release tablet may pass into your stool. Talk to your doctor if you see tablet pieces in your stool.

Oral routeIt is best to take this medicine with food or milk.

Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to empagliflozin or metformin, or if you have severe kidney disease (including patients receiving dialysis).

Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.

This medicine may cause some patients to become dehydrated. Drink plenty of water every day, during exercise, or in hot weather.

This medicine may cause the following problems:Lactic acidosis (too much acid in the blood)Low blood pressureKetoacidosis (high ketones and acid in the blood), which can be life-threateningKidney problemsLow blood sugar, when used with other diabetes medicineIncreased risk of genital yeast or urinary tract infections (including pyelonephritis, urosepsis)Increased risk for leg, foot, or toe amputationFournier's gangrene (skin or tissue damage of the area between the anus and genitals)

Tell your doctor if have kidney disease, liver disease, heart failure, vitamin B12 deficiency, or a history of pancreas problems, urinary tract or genital yeast infections, leg problems (including amputation, blood vessel disease), or foot infection, sores, or ulcers. Tell your doctor if you are on a low-salt diet, if you drink alcohol, or if you are having surgery or other procedures that require fasting.

Do not breastfeed during treatment with this medicine.

Tell your doctor if you are pregnant or planning to become pregnant. Do not use this medicine during the second and third part of your pregnancy, unless your doctor tells you to. It could harm an unborn baby. If you had problems ovulating or have irregular periods, this medicine may cause you to ovulate, which could lead to pregnancy if you are sexually active. Talk to your doctor about effective birth control while you are using this medicine.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may interact with the dye used for an x-ray or a CT scan.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Limit the amount of alcohol you drink. Heavy alcohol use increases your risk for lactic acidosis.

Limit the amount of alcohol you drink.

Some medicines can affect how empagliflozin/metformin works. Tell your doctor about all other medicines that you are using, including the following:Acetazolamide, amiloride, cimetidine, dichlorphenamide, digoxin, dolutegravir, isoniazid, lithium, morphine, nicotinic acid, procainamide, quinidine, quinine, ranitidine, ranolazine, topiramate, triamterene, trimethoprim, vancomycin, vandetanib, zonisamideBirth control pills (including estrogen)Blood pressure medicineDiuretic (water pill)Insulin or other diabetes medicineMedicine to treat mental illnessNSAID pain or arthritis medicine (including aspirin, celecoxib, diclofenac, ibuprofen, naproxen)Phenothiazine medicineSteroid medicineThyroid medicine

• Fast or trouble breathing, nausea, vomiting, stomach pain, severe weakness, tiredness
• Change in how much or how often you urinate, bloody urine, difficult or painful urination, lower back or side pain, chills
• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Lightheadedness, dizziness, fainting
• Pain, tenderness, redness, or swelling of the area between the anus and genitals, fever, unusual tiredness or weakness
• Increased hunger, confusion, shaking, trembling, sweating
• Pain, tenderness, sores or ulcers, or infections on the leg or foot
• Diarrhea, stomach upset, passing gas
• Stuffy or runny nose, sore throat
• White or yellow vaginal discharge, vaginal itching or odor
• Headache
• Redness, itching, pain, or swelling of the penis, bad-smelling discharge from the penis