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Drug Info for symtuza

The combination of darunavir, cobicistat, emtricitabine, and tenofovir is used to treat human immunodeficiency virus (HIV) infection in adults and children weighing at least 88 pounds (40 kg) who have not been treated with other HIV medications or to replace current medication therapy in certain people already taking HIV medications. The combination of darunavir, cobicistat, emtricitabine, and tenofovir is in a class of medications called antivirals. Darunavir, emtricitabine, and tenofovir work by decreasing the amount of HIV in the blood. Cobicistat helps to keep darunavir in the body longer so that the medication will have a greater effect. Although the combination of darunavir, cobicistat, emtricitabine, and tenofovir will not cure HIV, these medications may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other life-style changes may decrease the risk of transmitting the HIV virus to other people.

Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

Oral routeIt is best to take this medicine with food or milk.

If you cannot swallow the tablet whole, you may cut it into two using a tablet cutter. Take both halves of the tablet right away.

Your doctor will tell you how much medicine to use. Do not use more than directed.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Do not stop using this medicine without checking first with your doctor. If you stop the medicine even for a short time, the virus may become harder to treat. Contact your doctor or pharmacist when your supply is running low so you do not run out.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to darunavir, cobicistat, emtricitabine, or tenofovir alafenamide.

It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Birth control pills may not work as well to prevent pregnancy when used with this medicine. Use another form of birth control (including condoms or spermicide) along with your pills to keep from getting pregnant during treatment with this medicine.

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

This medicine may cause the following problems:Worsening of hepatitis B infection (if the medicine is stopped)Liver problemsSerious skin reactions, including Stevens-Johnson syndromeNew or worsening kidney problemsLactic acidosis (too much acid in the blood)High blood sugar level, which could become permanentIncreased risk of bleeding

Do not breastfeed. You can spread HIV or AIDS to your baby through your breast milk.

Tell your doctor if you have kidney disease, liver disease (including hepatitis B or C), diabetes, hemophilia, or an allergy to sulfa drugs.

This medicine will not keep you from giving HIV to others. Always practice safe sex, even if your partner also has HIV. Do not share needles or other items that may have blood or body fluids on them.

Your immune system may get stronger when you start taking HIV medicines. This could cause a hidden infection in your body to become active. Tell your doctor right away if you notice any changes in your health.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

There are many drugs that can interact with this medicine. Make sure your doctor knows about all other medicines you are using, especially the following:Acyclovir, artemether/lumefantrine, avanafil, bosentan, buspirone, cidofovir, cyclosporine, diazepam, estazolam, everolimus, fesoterodine, ganciclovir, gentamicin, salmeterol, sildenafil, sirolimus, solifenacin, tacrolimus, tadalafil, ticagrelor, valacyclovir, valganciclovir, vardenafil, zolpidemBirth control pillsBlood pressure medicine (including beta blockers, calcium channel blockers)Blood thinner (including apixaban, rivaroxaban, warfarin)Medicine for heart rhythm problems (including amiodarone, digoxin, disopyramide, flecainide, lidocaine, mexiletine, propafenone, quinidine)Medicine to lower cholesterol or triglycerides (including atorvastatin, fluvastatin, pravastatin, rosuvastatin)Medicine to treat an infection (including clarithromycin, erythromycin, isavuconazole, itraconazole, ketoconazole, posaconazole, rifabutin, rifapentine, telithromycin, voriconazole)Medicine to treat cancer (including dasatinib, nilotinib, vinblastine, vincristine)Medicine to treat depression or mental health problems (including quetiapine, trazodone, SSRIs, TCAs)Medicine to treat seizures (including clonazepam, eslicarbazepine, oxcarbazepine)Narcotic pain medicine (including buprenorphine, buprenorphine/naloxone, fentanyl, methadone, oxycodone, tramadol)NSAID pain or arthritis medicineSteroid medicine (including betamethasone, budesonide, dexamethasone)

Do not use this medicine together with alfuzosin, carbamazepine, dihydroergotamine, dronedarone, elbasvir/grazoprevir, ergotamine, ivabradine, lomitapide, lovastatin, lurasidone, methylergonovine, naloxegol, oral midazolam, phenobarbital, phenytoin, pimozide, ranolazine, rifampin, sildenafil, simvastatin, St John's wort, or triazolam.

Do not use this medicine together with colchicine if you have kidney or liver disease.

  • Blistering, peeling, or red skin rash
  • Fast breathing, trouble breathing, lightheadedness, severe weakness, tiredness, confusion
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Unusual bleeding, bruising, or weakness
  • Change in how much or how often you urinate, cloudy urine
  • Increased hunger or thirst
  • Weight gain around your neck, upper back, breast, or waist
  • Diarrhea