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$10.83 With Free Coupon
$14.82 With Free Coupon




$19.09 With Free Coupon
$20.69 With Free Coupon
$20.69 With Free Coupon
$21.59 With Free Coupon
$22.09 With Free Coupon
$22.09 With Free Coupon
$22.09 With Free Coupon
$22.09 With Free Coupon
$22.09 With Free Coupon
$22.09 With Free Coupon




$25.23 With Free Coupon




$31.38 With Free Coupon
$48.17 With Free Coupon
$78.86 With Free Coupon

Drug Info for methotrexate

Methotrexate is used to treat severe psoriasis (a skin disease in which red, scaly patches form on some areas of the body) that cannot be controlled by other treatments. Methotrexate is also used along with rest, physical therapy, and sometimes other medications to treat severe active rheumatoid arthritis (RA; a condition in which the body attacks its own joints, causing pain, swelling, and loss of function) that cannot be controlled by certain other medications. Methotrexate is also used to treat certain types of cancer including cancers that begin in the tissues that form around a fertilized egg in the uterus, breast cancer, lung cancer, certain cancers of the head and neck, certain types of lymphoma, and leukemia (cancer that begins in the white blood cells). Methotrexate is in a class of medications called antimetabolites. Methotrexate treats cancer by slowing the growth of cancer cells. Methotrexate treats psoriasis by slowing the growth of skin cells to stop scales from forming. Methotrexate may treat rheumatoid arthritis by decreasing the activity of the immune system.

Methotrexate is a medication used to treat certain types of cancers and autoimmune diseases. Methotrexate belongs to a class of medications called antifolate drugs. Methotrexate is a generic drug also sold under the trade names Trexall and Rasuvo. Methotrexate has been in use since the 1950s. In the treatment of cancers and autoimmune disease, methotrexate use is very common.

  • Trexall
  • Xatmep

Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. Do not take this medicine everyday to treat conditions other than cancer.

Oral liquid: Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

Tablet: Swallow whole. Do not crush, break, or chew it. Do not take the tablet if you cannot swallow it.

Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose. If you use this medicine only once a week and you miss a dose or forget to use your medicine, skip the missed dose and use your medicine as soon as possible. Return to your regular schedule the following week. Do not use extra medicine to make up for a missed dose.

You may store this medicine in the refrigerator or at room temperature. If stored at room temperature, throw it away after 60 days. Do not freeze or expose this medicine to high temperatures.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to methotrexate, or if you are pregnant or breastfeeding.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. If you are a woman who can bear children, your doctor may give you a pregnancy test before you start using this medicine to make sure you are not pregnant. Female patients should use an effective form of birth control during treatment and for at least 3 or 6 months after the last dose. Male patients who have female partners should use an effective form of birth control during treatment and for at least 3 months after the last dose.

Do not breastfeed during treatment and for at least 1 week after the last dose.

Tell your doctor if you have kidney disease, liver disease, blood or bone marrow problems (including anemia), diabetes, a weak immune system, any type of infection, stomach or bowel problem (including ulcers), lung or breathing problem, or a history of alcohol abuse.

This medicine may cause the following problems:Serious infections, which may be life-threateningKidney problemsStomach or bowel problems, including ulcer or perforationLiver problemsLung or breathing problems, including acute or chronic interstitial pneumonitisSerious skin reactions, including toxic epidermal necrolysis, Stevens-Johnson syndrome, exfoliative dermatitis, skin necrosis, or erythema multiformeIncreased risk of other cancers, including blood or skin cancerNerve problemsTumor lysis syndrome (electrolyte and metabolic problem that can be life-threatening)

This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.

Oral routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Do not take this medicine with foods that are rich in milk.

Do not drink alcohol while you are using this medicine.

Tell your doctor if you have used methotrexate before for any reason.

Talk to your doctor before getting flu shots or other vaccines while you are receiving methotrexate. Vaccines may not work as well while you are using this medicine.

Some foods and medicines can affect how methotrexate works. Tell your doctor if you are using any of the following:Acitretin, azathioprine, carbamazepine, cisplatin, clozapine, cyclosporine, foscarnet, phenytoin, pimecrolimus, probenecid, sulfasalazine, tacrolimus, theophyllineAntifolate medicine (including dapsone, pemetrexed, pyrimethamine, sulfonamides)Blood thinner (including warfarin)Diabetes medicine (including sulfonylureas)Medicine to treat an infection (including penicillin, sulfamethoxazole, trimethoprim/sulfamethoxazole, neomycin, tetracyclines)NSAIDs or pain medicine (including aspirin, diclofenac, ibuprofen, naproxen)Other cancer medicines, including radiation treatmentRetinoid medicineSalicylatesSteroid medicineStomach medicine (including esomeprazole, omeprazole, pantoprazole)Vitamin supplements containing folic acid

This medicine may interfere with vaccines. Ask your doctor before you get a flu shot or any other vaccines.

  • Change in how much or how often you urinate, lower back or side pain
  • Fever, chills, cough, sore throat, body aches
  • Chest pain, trouble breathing, blue lips or fingers
  • Rapid weight gain, swelling in your leg, ankles, or feet
  • Blistering, peeling, red skin rash
  • Dark urine or pale stools, nausea, vomiting, diarrhea, loss of appetite, stomach pain, yellow skin or eyes
  • Seizures, confusion, tingling or numbness in your hands, feet, or lips, trouble seeing, headache
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Unusual bleeding, bruising, tiredness, or weakness
  • Sores or white patches on your lips, mouth, or throat
Frequently Asked Questions

Methotrexate is a tablet used to treat the symptoms of psoriasis and certain types of cancer including breast and lung cancer. This medication is also used together with rest and physical therapy to relieve symptoms associated with rheumatoid arthritis. Methotrexate works by slowing the growth of specific cells in the body.

In addition to Methotrexate, several other similar brand-name drugs may be used to treat these symptoms including Rheumatrex Dose Pack and Trexall. Consult with your doctor to determine the best treatment for your condition.

The average Methotrexate cost depends on several things: insurance coverage, dosage, and the pharmacy where you shop. The average Methotrexate cash price for a supply of 24, 2.5 mg oral tablets is about $77.

Methotrexate is a generic drug. Similar brand-name drugs include Rheumatrex Dose Pack and Trexall. Our free coupon may be used for savings on Methotrexate and alternative brand-name drugs for savings of up to 80%.

Methotrexate oral tablets are only available in 2.5 mg strength. This medication is also as an injectable solution and injectable powder for injection. Follow your doctor's instructions for dosage and use of this medication.

There are several ways to save on Methotrexate. There is not a Methotrexate manufacturer coupon available at this time, but HealthWell Foundation Copay Program is a Patient Assistance Program that assists eligible patients with access to medications such as Methotrexate for free or at a savings. You can also use our free coupon. Our customers typically find that they save more by using our OptionRx savings card.