Kalydeco

Kalydeco is indicated for the treatment of cystic fibrosis in patients with one mutation in the CFTR (cystic fibrosis transmembrane conductance regulator) gene. Cystic fibrosis causes body secretions such as mucus and digestive juices to become thick and cause blockage in many organs. Kalydeco reduces the thickness of mucus and digestive juices to relieve symptoms of this condition. It is indicated for use by patients 2 years and older. This medication is available as a tablet.

• Kalydeco
• Symdeko

• Bronchitol
• Bronchitol Tolerance Test
• Kalydeco
• Orkambi
• Pulmozyme
• Symdeko
• Trikafta

• Granule
• Tablet

• By mouth

Your doctor will tell you how much medicine to use. Do not use more than directed.

Take this medicine with food that contains fat, including cheese pizza, eggs, butter, peanut butter, or whole-milk dairy products. This helps your body absorb the medicine better.

Oral granules: Shake the packet gently before you open it. Pour the contents into 1 teaspoon (5 milliliters) of room temperature or cold soft food or liquid (including applesauce, pureed fruits or vegetables, yogurt, water, breast milk, infant formula, milk, or juice) and mix together. Give this mixture within 1 hour and make sure all the medicine is taken. Give food that contains fat right before or right after you give the mixture.

Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

Missed dose: If it is 6 hours or less from the time you normally take your medicine, take a dose as soon as you can. If it is more than 6 hours, skip the missed dose and take your next dose at the regular time. Do not take extra medicine to make up for a missed dose.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to ivacaftor.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, or eye or vision problems (including cataracts).

This medicine may make you dizzy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Some foods and medicines can affect how ivacaftor works. Tell your doctor if you are using any of the following: Carbamazepine, clarithromycin, cyclosporine, digoxin, erythromycin, fluconazole, glimepiride, glipizide, itraconazole, ketoconazole, oral midazolam, phenobarbital, phenytoin, posaconazole, rifabutin, rifampin, St John's wort, tacrolimus, telithromycin, voriconazole, warfarin

Do not eat or drink anything that contains grapefruit or Seville oranges.

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Blurred vision or other changes in vision
• Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
• Fever, chills, cough, stuffy or runny nose, sore throat, body aches
• Mouth or throat pain
• Headache, dizziness
• Diarrhea