Imatinib Mesylate

( Generic Gleevec )

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Imatinib Mesylate

Drug Info for imatinib mesylate

Imatinib is used to treat certain types of leukemia (cancer that begins in the white blood cells) and other cancers and disorders of the blood cells. Imatinib is also used to treat certain types of gastrointestinal stromal tumors (GIST; a type of tumor that grows in the walls of the digestive passages and may spread to other parts of the body). Imatinib is also used to treat dermatofibrosarcoma protuberans (a tumor that forms under the top layer of skin) when the tumor cannot be removed surgically, has spread to other parts of the body, or has come back after surgery. Imatinib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells.

Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

Take this medicine with food and a large glass of water.

Swallow the tablet whole. Do not break or crush, break, or chew it.

If you cannot swallow the tablet, you may dissolve it in water or apple juice. After the tablet dissolves, stir the water or juice with a spoon and drink it immediately.100-milligram tablet: Dissolve it in 50 milliliters (mL) or 2 ounces (1/4 cup) of water or juice.400-milligram tablet: Dissolve it in 200 milliliters (mL) or 7 ounces (about 1 cup) of water or juice.

Do not handle crushed or broken tablets. Wash your skin with soap and water right away if you touch broken or crushed tablets.

Missed dose: If you miss a dose of this medicine, skip the missed dose and take your next dose when you normally would. Do not take extra medicine to make up for a missed dose.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to imatinib or if you are pregnant.

This medicine may make you dizzy or drowsy or cause blurry vision. Do not drive or do anything that could be dangerous until you know how this medicine affects you.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

Oral routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

Oral routeIt is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Use effective birth control during treatment and for 14 days after your treatment ends.

Tell your doctor if you have kidney disease, liver disease, or heart disease. Tell your doctor if you have had your thyroid removed.

Do not breastfeed during treatment and for 1 month after your last dose.

This medicine can cause the following problems:Heart problemsLiver problemsBleeding in your digestive system, which could be seriousTumor lysis syndromeSlow growth in children

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

Some foods and medicines can affect how imatinib works. Tell your doctor if you are using any of the following: Alfentanil, atazanavir, carbamazepine, clarithromycin, cyclosporine, dexamethasone, dihydroergotamine, ergotamine, erythromycin, fentanyl, fosphenytoin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, oxcarbazepine, phenobarbital, phenytoin, pimozide, primidone, quinidine, rifabutin, rifampin, rifampicin, ritonavir, saquinavir, simvastatin, sirolimus, St John's wort, tacrolimus, telithromycin, warfarin, or voriconazoleBlood pressure medicineIron supplementsStatin medicines

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

This medicine can cause the following problems:Heart problemsLiver problemsBleeding in your digestive system, which could be seriousTumor lysis syndrome

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

This medicine may make you dizzy or drowsy or cause blurry vision. Do not drive, use machines, or do anything that could be dangerous until you know how this medicine affects you.

This medicine may delay growth in children. If you think your child is not growing properly while using this medicine, talk with your doctor.

Oral routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, yellow skin or eyes
  • Decrease in how much or how often you urinate
  • Unusual bleeding, bruising, or weakness
  • Severe stomach pain, vomiting blood, or bloody or black, tarry stools
  • Rapid weight, swelling in your hands, ankles, or feet, trouble breathing, tiredness
  • Diarrhea
  • Muscle or joint pain
  • Headache