Buprenex

Buprenex comes in the form of an injectable solution and is used to treat moderate to severe pain. It works by binding to receptors in the brain, spinal cord and other areas of the body and reduces the transmission of pain signals to the brain. Buprenex can slow or stop your breathing, and may be habit-forming. Common side effects may include drowsiness, dizziness, nausea and vomiting.

• Buprenex

• Belbuca
• Bunavail
• Buprenex
• Buprenorphine
• Buprenorphine HCl
• Buprenorphine HCl-Naloxone HCl
• Butorphanol Tartrate
• Butrans
• Nalbuphine HCl
• Nubain
• Pentazocine-Naloxone HCl
• Probuphine Implant Kit
• Sublocade
• Suboxone
• Talwin
• Zubsolv

• Injectable

• By injection

An overdose can be dangerous. Follow directions carefully so you do not get too much medicine at one time. Your doctor may also give naloxone to treat an overdose.

Injection routeYour doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin, into a muscle, or into a vein.

Injection routeA nurse or other health provider will give you this medicine.

Injection routeYou may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.

Injection routeUse a new needle and syringe each time you inject your medicine.

This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

Missed dose: Injection routeCall your doctor or pharmacist for instructions.

Injection routeIf you store this medicine at home, keep it at room temperature, away from heat and direct light. Store the medicine in a safe and secure place. Drop off any unused narcotic medicine at a drug take-back location right away. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet. Check your local drug store and clinics for take-back locations. You can also check the DEA web site for locations. Here is the link to the FDA safe disposal of medicines website: www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/ensuringsafeuseofmedicine/safedisposalofmedicines/ucm186187.htm

Injection routeAsk your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine, containers, and other supplies. Throw away old medicine after the expiration date has passed.

Injection routeThrow away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to buprenorphine, or if you have severe breathing problems or stomach blockage (including paralytic ileus).

Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, gallbladder problems, lung disease or breathing problems (including COPD, sleep apnea), pancreas problems, an underactive thyroid, an adrenal problem, a spine deformity, problems with urination, an enlarged prostate, or a history of seizures, depression, or mental health problems. Tell your doctor if you have heart disease, congestive heart failure, a slow heartbeat, or a history of heart rhythm problems (including long QT syndrome). Tell your doctor if you have ever had a head injury, brain tumor, or stroke. Tell your doctor if you have ever been addicted to alcohol or drugs.

This medicine may cause the following problems:High risk of overdose, which can lead to deathRespiratory depression (serious breathing problem that can be life-threatening)Sleep-related breathing problems (including sleep apnea, sleep-related hypoxemia)Increased risk of serious injection site reactionsAdrenal gland problemsLiver problemsQT prolongation (heart rhythm problem)Serotonin syndrome (when used with certain medicines)

This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.

This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

Tell your doctor or anyone who treats you that you have been using Sublocade® injection within the last 6 months.

This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

Do not use this medicine if you are using or have used an MAO inhibitor within the past 14 days.

Some medicines can affect how buprenorphine works. Tell your doctor if you are using any of the following: Carbamazepine, cyclobenzaprine, erythromycin, ketoconazole, metaxalone, mirtazapine, phenobarbital, phenytoin, rifampin, tramadol, trazodone, valproic acidDiuretic (water pill)Medicine to treat depression, anxiety, or mental health problems (including SNRIs, SSRIs, TCAs)Medicine to treat heart rhythm problemMedicine to treat HIV infection (including atazanavir, delavirdine, efavirenz, etravirine, indinavir, nevirapine, ritonavir, saquinavir)Phenothiazine medicineTriptan medicine for migraine headaches

Do not drink alcohol while you are using this medicine.

Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol. Tell your doctor if you are using butorphanol, nalbuphine, pentazocine, a benzodiazepine, or a muscle relaxer.

• Changes in skin color, dark freckles, cold feeling, tiredness, weight loss
• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there
• Dark urine or pale stools, loss of appetite, yellow skin or eyes
• Blue lips, fingernails, or skin
• Extreme dizziness or weakness, shallow breathing, slow or uneven heartbeat, sweating, cold or clammy skin, seizures
• Fast, slow, or pounding heartbeat
• Severe constipation, stomach pain
• Lightheadedness, dizziness, fainting
• Drowsiness
• Mild nausea, vomiting, constipation, or diarrhea
• Mild nausea
• Pain, itching, burning, swelling, or lump under your skin where the needle is placed
• Pain, itching, burning, swelling, or lump under your skin where the needle is placed or shot given